{
  "_id": "6a103610acfb0bcc41c99f03",
  "Package": "ruminate",
  "Title": "A Pharmacometrics Data Transformation and Analysis Tool",
  "Version": "0.4.0",
  "Authors@R": "person(\"John\", \"Harrold\", , \"john.m.harrold@gmail.com\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0003-2052-4373\"))",
  "Description": "Exploration of pharmacometrics data involves both general\ntools (transformation and plotting) and specific techniques\n(non-compartmental analysis). This kind of exploration is\ngenerally accomplished by utilizing different packages. The\npurpose of 'ruminate' is to create a 'shiny' interface to make\nthese tools more broadly available while creating reproducible\nresults.  Currently there are modules for uploading one or more\ndatasets, data wrangling, plot genreation, non-compartmental\nanalysis, construction of ODE-based models, and constructing\nand running adaptive trial simualtions. Analyses can be saved\nand reloaded later. It's possible to create workflows to\nautomate analyses.  There is integrated reporting in Word,\nPowerpoint and Excel. You can also generate scripts to\nreplicate what was done in the app to create a stand-alone\nscript to run in validated environments.",
  "License": "BSD_2_clause + file LICENSE",
  "BugReports": "https://github.com/john-harrold/ruminate/issues",
  "URL": "https://ruminate.ubiquity.tools/",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.3",
  "Config/testthat/edition": "3",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev libfribidi-dev make libharfbuzz-dev libicu-dev\nlibjpeg-dev libpng-dev libtiff-dev libuv1-dev libwebp-dev\nlibxml2-dev libssl-dev libx11-dev zlib1g-dev",
  "Repository": "https://john-harrold.r-universe.dev",
  "Date/Publication": "2026-02-11 04:55:23 UTC",
  "RemoteUrl": "https://github.com/john-harrold/ruminate",
  "RemoteRef": "HEAD",
  "RemoteSha": "2b58cceec27d0ed72f243dc2f27bb45f1aa737b2",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-12 07:00:16 UTC",
    "User": "root"
  },
  "Author": "John Harrold [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-2052-4373>)",
  "Maintainer": "John Harrold <john.m.harrold@gmail.com>",
  "MD5sum": "8ed19dda7376c63cf123032fab608638",
  "_user": "john-harrold",
  "_type": "src",
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  "_created": "2026-05-12T07:00:16.000Z",
  "_published": "2026-05-22T10:55:12.612Z",
  "_distro": "noble",
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  "_buildurl": "https://github.com/r-universe/john-harrold/actions/runs/25718614824",
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  "_host": "GitHub-Actions",
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    "message": "Adding shinytest2 tests and updating the documentation\n",
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    "email": "john.m.harrold@gmail.com",
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    "bluesky": "@abumirchi.com",
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      "package": "DT",
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  "_usedby": 0,
  "_updates": [
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  "_contributors": [
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    "type": "user",
    "name": "John Harrold",
    "description": "I like math, and I make drugs.\r\n\r\n"
  },
  "_downloads": {
    "count": 224,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ruminate"
  },
  "_devurl": "https://github.com/john-harrold/ruminate",
  "_pkgdown": "https://ruminate.ubiquity.tools/",
  "_searchresults": 135,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/ruminate.html",
    "manual.pdf"
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  "_homeurl": "https://github.com/john-harrold/ruminate",
  "_realowner": "john-harrold",
  "_cranurl": true,
  "_releases": [
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      "date": "2023-08-29"
    },
    {
      "version": "0.2.0",
      "date": "2023-12-02"
    },
    {
      "version": "0.2.1",
      "date": "2023-12-11"
    },
    {
      "version": "0.2.2",
      "date": "2024-03-14"
    },
    {
      "version": "0.2.3",
      "date": "2024-05-18"
    },
    {
      "version": "0.2.4",
      "date": "2024-05-28"
    },
    {
      "version": "0.3.1",
      "date": "2025-01-10"
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  ],
  "_exports": [
    "apply_route_map",
    "CTS_add_covariate",
    "CTS_add_rule",
    "CTS_append_report",
    "CTS_change_source_model",
    "CTS_del_current_element",
    "CTS_fetch_code",
    "CTS_fetch_current_element",
    "CTS_fetch_ds",
    "CTS_fetch_sc_meta",
    "CTS_fetch_state",
    "CTS_init_state",
    "CTS_mk_preload",
    "CTS_new_element",
    "CTS_plot_element",
    "CTS_preload",
    "CTS_Server",
    "CTS_set_current_element",
    "CTS_sim_isgood",
    "CTS_simulate_element",
    "CTS_test_mksession",
    "CTS_update_checksum",
    "dose_records_builder",
    "fetch_rxinfo",
    "flag_nca_ds",
    "MB_append_report",
    "MB_build_code",
    "MB_del_current_element",
    "MB_fetch_appends",
    "MB_fetch_catalog",
    "MB_fetch_code",
    "MB_fetch_component",
    "MB_fetch_current_element",
    "MB_fetch_mdl",
    "MB_fetch_state",
    "MB_init_state",
    "MB_mk_preload",
    "MB_new_element",
    "MB_preload",
    "MB_Server",
    "MB_set_current_element",
    "MB_test_catalog",
    "MB_test_mksession",
    "MB_update_checksum",
    "MB_update_model",
    "mk_figure_ind_obs",
    "mk_rx_obj",
    "mk_subjects",
    "mk_table_ind_obs",
    "mk_table_ind_obs_flags",
    "mk_table_nca_params",
    "NCA_append_report",
    "nca_append_report_figs",
    "NCA_append_report_old",
    "nca_append_report_tbls",
    "nca_builder",
    "NCA_fetch_ana_ds",
    "NCA_fetch_ana_pknca",
    "NCA_fetch_code",
    "NCA_fetch_current_ana",
    "NCA_fetch_current_obj",
    "NCA_fetch_data_format",
    "NCA_fetch_ds",
    "NCA_fetch_np_meta",
    "NCA_fetch_PKNCA_meta",
    "NCA_fetch_state",
    "NCA_find_col",
    "NCA_mk_preload",
    "NCA_mkactive_ana",
    "NCA_new_ana",
    "NCA_preload",
    "NCA_process_current_ana",
    "NCA_reset_manual_flags",
    "NCA_Server",
    "NCA_set_current_ana",
    "NCA_test_mksession",
    "NCA_update_checksum",
    "plot_sr_ev",
    "plot_sr_tc",
    "ruminate",
    "ruminate_check",
    "run_nca_components",
    "rx2other",
    "simulate_rules"
  ],
  "_help": [
    {
      "page": "apply_route_map",
      "title": "Applies Route Mapping to Dataset",
      "topics": [
        "apply_route_map"
      ]
    },
    {
      "page": "CTS_add_covariate",
      "title": "Add Covariate to Elemetnt",
      "topics": [
        "CTS_add_covariate"
      ]
    },
    {
      "page": "CTS_add_rule",
      "title": "Add Rule to Element",
      "topics": [
        "CTS_add_rule"
      ]
    },
    {
      "page": "CTS_append_report",
      "title": "Append Report Elements",
      "topics": [
        "CTS_append_report"
      ]
    },
    {
      "page": "CTS_change_source_model",
      "title": "Change the Source Model",
      "topics": [
        "CTS_change_source_model"
      ]
    },
    {
      "page": "CTS_del_current_element",
      "title": "Deletes Current cohort",
      "topics": [
        "CTS_del_current_element"
      ]
    },
    {
      "page": "CTS_fetch_code",
      "title": "Fetch Module Code",
      "topics": [
        "CTS_fetch_code"
      ]
    },
    {
      "page": "CTS_fetch_current_element",
      "title": "Fetches Current cohort",
      "topics": [
        "CTS_fetch_current_element"
      ]
    },
    {
      "page": "CTS_fetch_ds",
      "title": "Fetch Clinical Trial Simulator Module Datasets",
      "topics": [
        "CTS_fetch_ds"
      ]
    },
    {
      "page": "CTS_fetch_sc_meta",
      "title": "Fetches Simulation Parameter Meta Information",
      "topics": [
        "CTS_fetch_sc_meta"
      ]
    },
    {
      "page": "CTS_fetch_state",
      "title": "Fetch Clinical Trial Simulator State",
      "topics": [
        "CTS_fetch_state"
      ]
    },
    {
      "page": "CTS_init_element_model",
      "title": "Initializes Cohort When Model Changes",
      "topics": [
        "CTS_init_element_model"
      ]
    },
    {
      "page": "CTS_init_state",
      "title": "Initialize CTS Module State",
      "topics": [
        "CTS_init_state"
      ]
    },
    {
      "page": "CTS_mk_preload",
      "title": "Make List of Current CTS State",
      "topics": [
        "CTS_mk_preload"
      ]
    },
    {
      "page": "CTS_new_element",
      "title": "New Clinical Trial Simulation Cohort",
      "topics": [
        "CTS_new_element"
      ]
    },
    {
      "page": "CTS_plot_element",
      "title": "Plots the Specified Element",
      "topics": [
        "CTS_plot_element"
      ]
    },
    {
      "page": "CTS_preload",
      "title": "Preload Data for CTS Module",
      "topics": [
        "CTS_preload"
      ]
    },
    {
      "page": "CTS_Server",
      "title": "Clinical Trial Simulator State Server",
      "topics": [
        "CTS_Server"
      ]
    },
    {
      "page": "CTS_set_current_element",
      "title": "Sets the Value for the Current cohort",
      "topics": [
        "CTS_set_current_element"
      ]
    },
    {
      "page": "CTS_sim_isgood",
      "title": "Checks Simulation in Element for Goodness",
      "topics": [
        "CTS_sim_isgood"
      ]
    },
    {
      "page": "CTS_simulate_element",
      "title": "Simulates the Specified Element",
      "topics": [
        "CTS_simulate_element"
      ]
    },
    {
      "page": "CTS_test_mksession",
      "title": "Populate Session Data for Module Testing",
      "topics": [
        "CTS_test_mksession"
      ]
    },
    {
      "page": "CTS_update_checksum",
      "title": "Updates CTS Module Checksum",
      "topics": [
        "CTS_update_checksum"
      ]
    },
    {
      "page": "dose_records_builder",
      "title": "Builds Dose Records Dataframe",
      "topics": [
        "dose_records_builder"
      ]
    },
    {
      "page": "fetch_rxinfo",
      "title": "Fetches Information from an rxode2 Object",
      "topics": [
        "fetch_rxinfo"
      ]
    },
    {
      "page": "fetch_rxtc",
      "title": "Extracts Timecourse and Merges Covariates",
      "topics": [
        "fetch_rxtc"
      ]
    },
    {
      "page": "flag_nca_ds",
      "title": "Creates Dataset Flags",
      "topics": [
        "flag_nca_ds"
      ]
    },
    {
      "page": "MB_append_report",
      "title": "Append Report Elements",
      "topics": [
        "MB_append_report"
      ]
    },
    {
      "page": "MB_build_code",
      "title": "Build Code to Generate Model",
      "topics": [
        "MB_build_code"
      ]
    },
    {
      "page": "MB_del_current_element",
      "title": "Deletes Current model",
      "topics": [
        "MB_del_current_element"
      ]
    },
    {
      "page": "MB_fetch_appends",
      "title": "Fetches List of Available Models",
      "topics": [
        "MB_fetch_appends"
      ]
    },
    {
      "page": "MB_fetch_catalog",
      "title": "Fetches List of Available Models",
      "topics": [
        "MB_fetch_catalog"
      ]
    },
    {
      "page": "MB_fetch_code",
      "title": "Fetch Module Code",
      "topics": [
        "MB_fetch_code"
      ]
    },
    {
      "page": "MB_fetch_component",
      "title": "Fetch Selected Current Model Component",
      "topics": [
        "MB_fetch_component"
      ]
    },
    {
      "page": "MB_fetch_current_element",
      "title": "Fetches Current model",
      "topics": [
        "MB_fetch_current_element"
      ]
    },
    {
      "page": "MB_fetch_mdl",
      "title": "Fetch Model Builder Module Models",
      "topics": [
        "MB_fetch_mdl"
      ]
    },
    {
      "page": "MB_fetch_state",
      "title": "Fetch Model Builder State",
      "topics": [
        "MB_fetch_state"
      ]
    },
    {
      "page": "MB_init_state",
      "title": "Initialize MB Module State",
      "topics": [
        "MB_init_state"
      ]
    },
    {
      "page": "MB_mk_preload",
      "title": "Make List of Current MB State",
      "topics": [
        "MB_mk_preload"
      ]
    },
    {
      "page": "MB_new_element",
      "title": "New Model Building Model",
      "topics": [
        "MB_new_element"
      ]
    },
    {
      "page": "MB_preload",
      "title": "Preload Data for MB Module",
      "topics": [
        "MB_preload"
      ]
    },
    {
      "page": "MB_Server",
      "title": "Model Builder State Server",
      "topics": [
        "MB_Server"
      ]
    },
    {
      "page": "MB_set_current_element",
      "title": "Sets the Value for the Current model",
      "topics": [
        "MB_set_current_element"
      ]
    },
    {
      "page": "MB_test_catalog",
      "title": "Tests the Model Catalog",
      "topics": [
        "MB_test_catalog"
      ]
    },
    {
      "page": "MB_test_mksession",
      "title": "Populate Session Data for Module Testing",
      "topics": [
        "MB_test_mksession"
      ]
    },
    {
      "page": "MB_update_checksum",
      "title": "Update MB Module Checksum",
      "topics": [
        "MB_update_checksum"
      ]
    },
    {
      "page": "MB_update_model",
      "title": "Updates Current Element with rxode2 Model",
      "topics": [
        "MB_update_model"
      ]
    },
    {
      "page": "mk_figure_ind_obs",
      "title": "Creates Figures of Individual Observations from PKNCA Result",
      "topics": [
        "mk_figure_ind_obs"
      ]
    },
    {
      "page": "mk_rx_obj",
      "title": "Makes an rxode2 Object",
      "topics": [
        "mk_rx_obj"
      ]
    },
    {
      "page": "mk_subjects",
      "title": "Fetches Information from an rxode2 Object",
      "topics": [
        "mk_subjects"
      ]
    },
    {
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